Design of an Ethnopharmacological Membrane: Properties and Applications
Resumen
The growing interest in wound care treatments using nanostructured dressings based on bioconjugated polymers incorporating plant extracts and metallic nanoparticles highlights the importance of these innovations in skin regeneration. In this study, gold nanoparticles (AuNPs) were biosynthesized using lyophilized extracts from the gel and epicarp of Aloe vera in a 6:4 ratio with chloroauric acid (HAuCl4) and incorporated into electrospun polyvinylpyrrolidone (PVP) membranes. The AuNPs were characterized by UV-Vis, FTIR, and TEM, exhibiting a surface plasmon resonance band at 524 nm and average sizes of 12 and 18 nm. FTIR analysis revealed bands corresponding to –OH, C=O, and C–O–C groups, which were also present in the extracts, suggesting their role in the reduction and stabilization of the nanoparticles. The membranes were evaluated by FTIR and SEM, revealing spectral changes attributed to the presence of AuNPs. EDS analysis confirmed the successful incorporation of gold into the nanofibrous matrix. Finally, the wound-healing effect of the AuNP-incorporated membranes was studied using a murine model.